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Hartman et al conducted a study of exercise-induced DNA damage in human subjects using DNA strand breaks in white blood cells as a biomarker (16), and found that supplementation with vitamin E for 2 weeks was effective in reducing DNA damage after an incremental exercise test to exhaustion

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However, since circulating oxylipin profiles are unlikely to represent tissue profiles, and as we have previously shown that ibuprofen was associated with proteasome and metabolic dysfunction in livers 27 , the oxylipin profiles of livers from ibuprofen treated mice were investigated